Abstract: Carica papaya, commonly known as papaya, is a tropical fruit widely consumed for its digestive and nutritional benefits. While its fruit pulp is valued, the seeds are often discarded. However, scientific studies have revealed that matured papaya seeds possess high nutritional and medicinal value due to the presence of proteins, fats, dietary fiber, essential minerals, and active enzymes such as papain. This research investigates the chemical composition of matured papaya seeds and explores the therapeutic application of papaya seed powder in managing renal and gall bladder stones. Proximate analysis and a preliminary observational study on patients suffering from urolithiasis and cholelithiasis were conducted. Results indicate a rich composition of macronutrients and minerals along with significant relief in symptoms among patients. This study supports the potential of papaya seed powder as a natural supplement in stone management.

Keywords : Papaya seed powder, kidney stones, gall bladder stones, papain enzyme, litholytic therapy, Carica papaya, nutraceuticals, phytochemicals .